China under the almighty leadership of Xi Jinping has created yet another breakthrough – Gay Babies!
No, the babies may not be gay, but the parents are gay in the experiment.
Is this the reason why Tim Cook is so obsessed with China?
Mouse pups with same-sex parents born in China using stem cells and gene editing
The South China Morning PostĀ reportsĀ that āChinese scientists have produced healthy mouse pups from two female parents with the help of DNA editing,Ā according to a studyĀ published in the American scientific journalĀ Cell Stem Cell.ā
- The team had previouslyĀ āderived mice with two female parents,ā but they suffered from birth defects. This time, the mouse pups were healthy.
- The scientists also createdĀ mouse pups from two male parents, but they survived only a couple of days. In total, they produced 29 live mice from 210 embryos.
- Same-sex reproduction is difficultĀ for mammals ābecause of a mechanism called genomic imprinting,ā but the Chinese team was able to āmimic the presence of DNA from both genders by deleting certain genes.ā
- Monkeys are next,Ā according to one of the scientists, but he denied plans to use the techniques on people: āWe cannot assert this technique can never be used in humans in the future. But for now, the answer is no,ā he said.
Paris Hilton: “Can they clone boobs?”
“We were interested in the question of why mammals can only undergo sexual reproduction. We have made several findings in the past by combining reproduction and regeneration, so we tried to find out whether more normal mice with two female parents, or even mice with two male parents, could be produced using haploid embryonic stem cells with gene deletions,” says co-senior author Qi Zhou.
While some reptiles, amphibians, and fish can reproduce with one parent of the same sex, it’s challenging for mammals to do the same even with the help of fertilization technology. In mammals, because certain maternal or paternal genes are shut off during germline development by a mechanism calledĀ genomic imprinting, offspring that don’t receive genetic material from both a mother and a father might experience developmental abnormalities or might not be viable. By deleting these imprinted genes from immature eggs, researchers have produced bimaternal miceāmice with two mothersāin the past. “However, the generated mice still showed defective features, and the method itself is very impractical and hard to use,” says Zhou.
To produce their healthy bimaternal mice, Zhou, co-senior author Baoyang Hu, co-senior author Wei Li, and their colleagues used haploid embryonic stem cells (ESCs), which contain half the normal number of chromosomes and DNA from only one parent and which the researchers believe were the key to their success. The researchers created the mice with two mothers by deleting three imprinting regions of the genome from haploid ESCs containing a female parent’s DNA and injected them into eggs from another female mouse. They produced 29 live mice from 210 embryos. The mice were normal, lived to adulthood, and had babies of their own.
One advantage of using haploid ESCs is that even before the problematic genes are knocked out, they contain less of the imprinting programming that ultimately causes maternal- or paternal-specific genes to be expressed. “We found in this study that haploid ESCs were more similar to primordial germ cells, the precursors of eggs and sperm. The genomic imprinting that’s found in gametes was ‘erased,'” says Hu.
Twelve live, full-term mice with two genetic fathers were produced using a similar but more complicated procedure. Haploid ESCs containing only a male parent’s DNA were modified to delete seven key imprinted regions. The edited haploid ESCs were then injectedāalong with sperm from another male mouseāinto an egg cell that had its nucleus, and therefore its female genetic material, removed. This created an embryo containing only genomic DNA from the two male parents. These embryos were transferred along with placental material to surrogate mothers, who carried them to term.
These pups survived 48 hours after birth, but the researchers are planning to improve the process so that the bipaternal mice live to adulthood. Similar results were achieved in 2011 but using a method that relied on a female intermediary produced from the first father’s stemĀ cellsĀ to mate with theĀ second father. That method sidestepped the problem of genomic imprinting but presents ethical and practical hurdles if this technology were to ever be considered for humans.
Li notes that there are still obstacles to using these methods in other mammals, including the need to identify problematic imprintedĀ genesĀ that are unique to each species and concerns for the offspring that don’t survive or that experience severe abnormalities. They do hope, however, to explore these techniques in other research animals in the future.
“This research shows us what’s possible,” he says. “We saw that the defects in bimaternal mice can be eliminated and that bipaternal reproduction barriers in mammals can also be crossed through imprinting modification. We also revealed some of the most important imprinted regions that hinder the development ofĀ miceĀ with same sex parents, which are also interesting for studying genomic imprinting and animal cloning.”